After her split from Scott Foley, Jennifer Garner began dating her Alias co-star Michael Vartan.
The pair was a couple both on and off screen before splitting in 2004.
After Jamie-Lynn Sigler's guest-starring role as a love interest of Jerry Ferrara's character Turtle on Entourage in 2008, the two began a real-life relationship.
They kept their love under wraps for the most part but called it quits a year later.
The pair dated on and off for four years before splitting in 2012, though they may have rekindled their relationship — they were spotted getting close during an airport sendoff in April 2013.
Jennifer Morrison and Jesse Spencer met in 2004 while shooting the pilot for House.
Unfortunately, just like in their onscreen relationship, the couple called it quits — they annulled their marriage and separated just five months later.
But fans were shocked when not only did Sean and Rachel stay together, they got married and had children — eight of them, to be exact! After the show, the two got engaged and later married. Nina and Ian aren't the first TV co-stars to strike up a romantic relationship — small-screen duos like Rachel Bilson and Adam Brody, Blake Lively and Penn Badgley, and Vanessa Hudgens and Zac Efron also hooked up during their downtime, and leading ladies like Jennifer Garner, Emily Van Camp and Sophia Bush were lucky enough to find love on more than one set.Click through to see 30 couples that took their love off screen — and even worked together well past their demise.Gossip Girl co-stars Leighton Meester and Sebastian Stan dated for two years before calling it quits in 2010.Of the relationship, Leighton told Seventeen magazine, "I was really sad when it ended." Leighton is now reportedly dating Adam Brody, while Sebastian has been linked to Dianna Agron and Jennifer Morrison.