From his re-occurring character ‘Bob,’ the “angry gay Puerto Rican,” on Seinfeld, to one of Samantha’s love interests on HBO’s Sex and the City, to 'Rueben the Cuban' on HBO’s The Sopranos.
Other television include Law & Order: SVU (NBC) and Fringe (Fox).
Shortly after graduating she appeared in Adam Rapp’s Red Light Winter which premiered at the Steppenwolf Theatre Company before transferring off-Broadway and being named a finalist for the Pulitzer Prize.
He starred in Sea of Tranquility at the Atlantic Theatre Company and received rave reviews for his role in Tony Kushner’s Homebody/Kabul at the New York Theatre Workshop.
Additionally he recurs in three other television shows, as ‘Pedro’ in FX’s Louie, as ‘Christian’ in CBS’ The Good Wife and as 'Detective Anthony Nikolich’ on HBO’s Treme.
Vázquez starred on Broadway in the Tony nominated The Motherf**cker with the Hat opposite Chris Rock.
Other film credits include The A-Team (Fox) opposite Bradley Cooper and Liam Neeson, John Sayles’ Amigo opposite Chris Cooper, Salvation Boulevard (Mandalay) opposite Jennifer Connolly, Pierce Brosnan, Marisa Tomei and Greg Kinnear, Little Fockers (Universal) with Robert De Niro and Ben Stiller, Ridley Scott’s American Gangster (Universal) alongside Russell Crowe and Denzel Washington (a 2008 SAG nominee for Outstanding Performance by a Cast in a Motion Picture), Steven Spielberg’s War of the Worlds, (Dreamworks) opposite Tom Cruise, Bad Boys II (Columbia) opposite Martin Lawrence and Will Smith, Runaway Bride (Paramount) opposite Julia Roberts and Nick of Time (Paramount) opposite Johnny Depp.
He reunited with director Steven Soderbergh to star opposite Benicio Del Toro in Che (IFC).